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Segmentalexcision of an infected nonunion will produce a bone defect that can be managed in asingle procedure or in stages.

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It was found,that when expressed in low levels, Mdm2 can mediate p53-monoubiquitination, whichsignals for p53 nuclear export and leads to its accumulation in the cytoplasm, therebyinhibiting its role as transcription factor [72, 73]. In individuals of European descent, the carrierrate for one mutation, c.35delG, approximates 1/50 [ 20 , 21]

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Earlier studies implicated 100amino acid residues at the N-terminus of MDM2 in interacting with p53 [ 35 , 36 ].Later reports suggest that binding of p53 with MDM2 induces a conformationalchange in WT p53 leading to secondary binding of the central acidic domain ofMDM2 to the DNA-binding domain of p53 [ 37 – 40]. Therefore Seroquel generic a meaningful quantitative evaluation is only possible ina minority of the published case series.

p53 can be also activated viaredox-dependent mechanisms involving redox factor Ref1 [95].

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